Alzheimer’s Researchers Admit That Experiments on Animals Are a Big Fat Failure

Written by PETA | November 28, 2018

Update: Chalk up another epic fail for Alzheimer’s disease experiments on animals.

At a recent scientific conference, not one but three pharmaceutical companies announced the stunning failures of experimental Alzheimer’s drugs that had tested successfully in mice—who must be genetically engineered to develop a pseudo-Alzheimer’s condition. The compounds—known as BACE inhibitors—actually appeared to hurt patients by worsening their cognitive abilities and causing brain shrinkage.

Here’s how the journal Nature describes this increasingly long list of treatment disappointments: “Drug companies have spent billions of dollars searching for therapies to reverse or significantly slow Alzheimer’s disease, to no avail.”

Alzheimer’s patients deserve so much better than this. As one molecular biologist put it, “The biggest mistake you can make is to think you can ever have a mouse with Alzheimer’s disease.”

Experimenters must adopt superior, non-animal research methods that are actually relevant to human physiology. For example, a just-published “landmark” study using cells from human brains has provided new insight into how Alzheimer’s develops and may lead to effective treatments.

Originally posted on April 3, 2017:

After a string of failures, experimenters are finally realizing that the way they’ve been trying to develop treatments for Alzheimer’s disease has gotten them nowhere.

Gee, that only took decades of wasted time and money, more than 100 failed drugs, and an untold number of animals’ lives.

Close up horizontal shot of a domestic gray and white rat looking into the camera.

© iStock.com/Eponaleah 

For years, experimenters have tormented mice, dogs, and other animals in an effort to come up with drugs to treat Alzheimer’s disease. Trouble is, those animals don’t get Alzheimer’s. So experimenters manipulate an animal’s genome to force the buildup of amyloid plaques similar to those in the brains of people with the disease. The result: Animals seem to have relief from symptoms that look like Alzheimer’s—but aren’t.

In the meantime, human patients continue to suffer.

The failure rate in humans for new Alzheimer’s drugs now stands at a staggering 99.6 percent. You can include Eli Lilly’s much-hyped solanezumab among those duds. That drug had been tested successfully in mice and monkeys. But it turned out to be an abject failure in clinical trials.

Now that experimenters admit that they’ve made just about zero progress, it’s time they took their heads out of the sand and rejected the use of animal “models” that can never replicate human forms of dementia.

Instead, they should adopt superior, non-animal research methods that are actually relevant to human physiology.

What You Can Do

Support Alzheimer’s charities that actually help people and don’t test on animals.

And urge your congressional representatives to demand that the National Institutes of Health stop wasting our tax dollars funding pointless animal experiments and instead focus on modern, non-animal methods of research.

Meet 10 Dogs Who Were Exploited by Hemopet for Blood

Greyhounds used in the racing industry are treated like unfeeling machines and run until their bodies are broken and destroyed. But for many of those dogs, “retirement” means even more suffering.

A PETA eyewitness investigation revealed that the canine blood bank Hemopet—which claims to be a “rescue” facility for discarded greyhounds—keeps around 200 dogs in tiny crates and barren, rusty kennels for about 23 hours out of every day. These greyhounds—who, like all dogs, are eager to run and play and long for companionship—are reduced to being bled for cash.

Sick, suffering, and stressed, these dogs have been forgotten by the world, but PETA wants you to know some of their stories.

Glory (DOB: March 1, 2014)

Under the racing name Gloryusfinish, Glory was raced over 160 times before she was discarded at Hemopet, where she was bitten on the back by her stressed kennelmate. After her wound healed, the kennel supervisor put her back in the pen with the same dog who’d bitten her—despite a warning by another staff member that the two were not a good match—with instructions to keep them muzzled and deny them toys.

PETA exposes Hemopet

Gibbs (DOB: Unknown)

Gibbs reportedly suffered from a neurological disorder that often involves tumors in the chest. He quickly became lethargic and barely responded to his own name. A much-needed veterinary appointment was never made for him, according to Hemopet staff. He was left crated for weeks until a worker found blood in his water bowl. He was finally euthanized after an X-ray revealed that he had a large mass on or near his lungs.

PETA exposes Hemopet

Pidgeon (DOB: Unknown)

Pidgeon was apparently attacked by her kennelmate, resulting in gashes on her neck that required stitches.

PETA exposes Hemopet

Melyn (DOB: Unknown)

Melyn required sutures on her chin after her kennelmate bit her, but staff reportedly went home for the night, leaving the open wound untreated until the next day.

Bunny (DOB: Unknown)

Bunny suffered from a cough that had apparently persisted for over a year. Her blood was still taken to be sold, despite her ailing condition.

WendyLu (DOB: April 11, 2016)

WendyLu had red, peeling skin on her nose. Hemopet staff speculated that she had lupus but said that no tests had ever been run to diagnose her. Dogs with this disease can have a low platelet count, but her blood was taken, anyway—even though it may not have contained all the components that dogs who are given blood transfusions urgently need.

PETA exposes Hemopet

Lennon (DOB: May 30, 2016)

Workers said that Lennon also suffered from lupus-like symptoms, including an apparent rash all over his body. And like they did to WendyLu, they took his blood, even though a staffer said that “lupus is an autoimmune disease … they probably shouldn’t donate.”

PETA exposes Hemopet

Genie (DOB: Unknown)

Like many of the other dogs at Hemopet, Genie was missing hair. She also had red, irritated skin on her leg. A veterinarian said, “In my professional assessment, the high number of dogs with areas of hair loss and callused skin is indicative that the dogs are chronically suffering from long-term excessive confinement, with limited opportunity for mobility and activity necessary for optimal health and welfare” [emphasis added].

PETA exposes Hemopet

Puppet (DOB: September 26, 2013) and Val (DOB: Unknown)

Staff housed Puppet and Val—who were both prone to seizures—in small, unpadded metal crates amid loud noises and left them unattended overnight. Puppet evidently injured himself during a seizure. A staffer said that Val—who’d been ditched at the facility by his adopter because of his seizures—needed a brain scan. The staffer said that Val “could be in a lot of pain and no one would know.”

*****

Dogs like these deserve homes, not cages. Here’s what you can do.

Don’t allow greyhounds to continue to suffer where no one can see them. Share these stories with your friends and family. Demand that the National Greyhound Association (NGA) bar its members’ dogs from being held captive in blood banks—including those operated by purported rescue organizations—effective immediately.